An Unbiased View of pkrrating
The interfacial residues are extremely conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements reveal which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations help a product where activating RNA serves like a scaffold to bind many PKR monomers, growing the are